DPP4-directed therapeutic strategies for MERS-CoV
نویسندگان
چکیده
منابع مشابه
MERS-CoV
In 2002/03, a novel coronavirus (CoV) termed severe acute respiratory syndrome (SARS)-CoV emerged in China and caused an epidemic in which approximately 800 of 8000 cases died. Ten years later, a newly emerged Middle East respiratory syndrome (MERS)-CoV has been confirmed in 189 patients of which 82 had a fatal outcome. All MERS cases were linked to the Arabian Peninsula and to date thirteen ca...
متن کاملمروری بر MERS-CoV
(MERS) یک بیماری ویروسی تنفسی است که اولین بار در سپتامبر 2012 در جده عربستان سعودی گزارش شد. عامل بیماری، یک ویروس جدید از گروه بتاکوروناویروسها است که تا این مرحله منشاء آن نامشخص است؛ ولی مطالعات ژنتیکی حاکی از آن است که کوروناویروسهای خفاش بیشترین نزدیکی را به این ویروس دارند. به طور کلی، MERS-CoV به نظر یک ویروس حیوانی است که به صورت اسپورادیک و با انتقال محدود، منجر به عفونت در انسان می...
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We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a reservoir in nature.
متن کاملMERS-CoV diagnosis: An update.
Diagnosis of MERS-Cov still a major concern in most of daignostic laboratories. To date the Real-time Polymerase Chain reaction (RT-PCR) is the mainstay for diagnosis of MERS-CoV. RT-PCR has limitations, including a long turnaround time and lack of common measurements and correlations with Viral Load (VL). It is recommended to screen for MERS-CoV using RT-PCR of the upstream of envelope gene (u...
متن کاملMERS-CoV: An Epidemic Whirlwind
Corona virus as a Middle East Respiratory Syndrome (MERS) considered being a new complicated disease; it infects the epithelial cells in the respiratory and/or intestinal tracts, thus causing disease in epidemic proportions. The situation is exacerbated by either a short incubation period between 2-7 days or between 12-14 days. In September 2012, coronavirus was identified for the first time in...
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ژورنال
عنوان ژورنال: The Lancet Infectious Diseases
سال: 2014
ISSN: 1473-3099
DOI: 10.1016/s1473-3099(13)70696-0